The short answer is: YES!
If a specimen or biological material can transition through the freezing point — as happens when frozen in refrigerators and/or packed in dry ice — then holding it at liquid nitrogen temperatures will not harm the specimen. In fact, it will most likely have a positive impact. Cryoport’s Global Cryogenic Shipping Solution is specifically developed to sustain temperatures below the glass point (-136°C). This means all metabolic processes and certain degradative reactions will cease at these lower temperatures, which will extend the viability and function of the specimen.
LN2 does not affect the samples. The specimens placed into a Cryoport Express® dry vapor shipper do not come into contact with the liquid nitrogen. Typically, the specimens will not come in contact with the nitrogen gas either, as they are usually packaged in a leak-proof, pressure-proof shipping enclosure in compliance with the IATA (International Air Transport Association (IATA) such as a medical grade Tyvek® bag (supplied by Cryoport along with the shipper).
Cryoport has conducted publication quality research on the impact of packaging choices on research and clinical trial research materials. We are using this data to design, provide, and support intelligent logistics solutions to the industry that mitigate the impact of logistics on sample integrity and performance.
Packaging and logistics decisions directly impact the quality of your samples.
- 30% of the biomarkers tested require cryogenic transport for consistent recovery.
- Cryogenic logistics significantly reduces thermal cycling during transport when compared to dry ice shipping (undocumented freeze-thaw cycles).
- Sample pH is impacted in a directly proportional level to duration of shipment on dry ice.
Clinical efficacy, bioanalytical and manufacturing issues encountered may in fact be logistics issues.
- Cryogenic shipping significantly lowered the standard deviation of the samples tested in this study when compared to dry ice shipping.
Cryogenic logistics is critical for the transport of cell-based reagents for manufacturing.
- Cryogenic transportation of a cell therapy resulted in optimum viability of the cells vs. dry ice shipping
In short, a strategic packaging consideration and approach for your global supply chain is critical and considering a fully integrated cryogenic shipping solution providing chain of custody; condition and compliance for your time and temperature sensitive biological materials, is the way forward!
Written by: Soren H. Knudsen, Commercial Director, EMEA, Cryoport
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